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GlyTR1 CAR T cells
- Development stage
- Preclinical
- Lead developer
- University of California, Irvine
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
GlyTR1 CAR T cells are an experimental chimeric antigen receptor (CAR) T-cell therapy designed to target Tumor Associated Carbohydrate Antigens (TACAs), specifically β1,6GlcNAc-branched N-glycans. Developed using the Glycan-dependent T cell Recruiter (GlyTR) technology, these cells utilize high-avidity, velcro-like lectin binding rather than traditional high-affinity antibody binding. This mechanism allows the CAR T cells to selectively kill cells with high TACA density (typical of cancer cells) while sparing normal tissues with low TACA expression, thereby reducing on-target, off-cancer toxicity. The project is supported by the NCI Cancer Moonshot program and has shown pan-cancer activity in preclinical models.
- Other names
- GlyTR1 CAR-TGlyTR-1 CAR-TGlyTR 1 CAR-T
02
Targets
Beta-1,6-GlcNAc-branched N-glycanCD3 (T-cell surface glycoprotein CD3)
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