GM-CT-01 + 5-fluorouracil

GM-CT-01 + 5-fluorouracil is a **combination therapy** under investigation and clinical testing for cancer, primarily **colorectal cancer, metastatic melanoma**, and other solid tumors. GM-CT-01 (DAVANAT) is a chemically modified galactomannan polymer extracted from guar seeds, designed to act as a **galectin antagonist** by blocking the interaction of galectin-1 and galectin-3 with glycosylated receptors on tumor-infiltrating lymphocytes (TILs). This blockade restores and enhances the cytotoxicity and interferon gamma secretion of T cells, boosts immune-mediated tumor killing, and potentially improves the efficacy of conventional chemotherapeutics. 5-fluorouracil (5-FU) is a **pyrimidine antimetabolite** that inhibits thymidylate synthase, blocking DNA synthesis and leading to cancer cell death. The combination has shown to reduce toxicity of 5-FU and raise anti-tumor response rates in preclinical and clinical studies[2][6][8].

Brand names

DAVANAT

Other names

GM-CT-01GM-CT01GM-CT 01DAVANAT5-fluorouracil