GM.CD40L cells

GM.CD40L cells are a human bystander cell line created at the Moffitt Cancer Center that expresses both granulocyte-macrophage colony-stimulating factor (GM-CSF) and CD40 ligand (CD40L). These cells are used to generate an allogeneic tumor cell-based vaccine formulation for cancer immunotherapy. The bystander cells help recruit professional antigen-presenting cells (dendritic cells) by secreting GM-CSF in the vaccine site microenvironment. Once activated by CD40L, dendritic cells take up apoptotic bodies from irradiated tumor cells in the vaccine and present tumor antigens. These activated dendritic cells migrate to regional lymph nodes, where T-cell activation occurs, leading to systemic tumor cell killing.

Other names

K562-GMCSF-CD40L vaccineK-562-GMCSF-CD40L vaccineK 562-GMCSF-CD40L vaccinebystander vaccine