GMAB-RNA complex

GMAB-RNA complex is an experimental **antibody-based RNA delivery therapeutic platform** developed by **Gennao Bio** and licensed from **Yale University**. The construct consists of a proprietary **cell-penetrating gene monoclonal antibody** non-covalently complexed with a therapeutic RNA payload, creating a biologic designed for **systemic, non-viral nucleic acid delivery**. In preclinical oncology work, GMAB-RNA complexes have been used to deliver immunostimulatory RNAs, including **3p-hpRNA**, into tumors such as melanoma, medulloblastoma, and other central nervous system tumors, where activation of innate immune signaling has been associated with tumor growth suppression and reduced tumor burden in mouse models. The platform has also been described by the company as applicable to **monogenic skeletal muscle diseases**, but the specific therapeutic cargo and product-level clinical candidate corresponding to the exact name GMAB-RNA complex have not been clearly defined publicly.

Other names

gene monoclonal antibody RNA complexantibody-RNA complex