Drug intelligence / Profile preview

GMMI V-FORTE

Development stage
Unknown
Lead developer
El Dorado Bio Tech
Modality
Small Molecules
Administration
Oral
01

Overview

GMMI V-FORTE is a fixed-dose combination (FDC) oral hypoglycemic agent developed and marketed by El Dorado Bio Tech Pvt. Ltd. for the management of type 2 diabetes mellitus. The formulation contains three active pharmaceutical ingredients with complementary mechanisms of action: Voglibose (0.3 mg), Metformin Hydrochloride (1000 mg), and Glimepiride (3 mg). Voglibose is an alpha-glucosidase inhibitor that delays the digestion and absorption of carbohydrates in the small intestine, thereby reducing postprandial blood glucose levels. Metformin, a biguanide, improves glycemic control by decreasing hepatic glucose production and increasing peripheral insulin sensitivity. Glimepiride is a third-generation sulfonylurea that stimulates the release of insulin from pancreatic beta cells by blocking ATP-sensitive potassium channels. This triple combination therapy is typically indicated for patients whose blood sugar levels are not adequately controlled by dual therapy with metformin and a sulfonylurea. The product is approved and marketed in India.

Brand names
GMMI V-FORTEGMM V FORTE
Other names
voglibose + metformin + glimepiride
02

Targets

Sucrase-IsomaltaseKATP channel (ATP-sensitive potassium channel)ND1 (Mitochondrial electron transport chain complex I)

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