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GNPs-Dox-Lac

Development stage: Preclinical
Modality: Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Intravenous

Overview

**GNPs-Dox-Lac** is an experimental, enzyme-responsive and pH-responsive nanomedicine for hepatocellular carcinoma. It consists of gelatin nanoparticles carrying a lactose-conjugated doxorubicin prodrug, doxorubicin-lactose. The approximately 133 nm gelatin carrier is designed to remain stable during circulation and accumulate in tumors; tumor-associated matrix metalloproteinase-2 degrades the gelatin matrix, releasing the smaller doxorubicin-lactose prodrug to improve tumor penetration and cellular uptake. Intracellular acidic conditions then dissociate the prodrug and release free doxorubicin, which intercalates DNA and inhibits topoisomerase II, causing DNA damage and cytotoxicity. In an in vivo hepatocellular carcinoma model, the system produced a reported tumor-inhibition rate of 90.8% with comparatively low toxicity.

Other names: GNPs-DOX-Lac

Targets

TOP2B (DNA topoisomerase II beta)DNATOP2A (DNA topoisomerase II)

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