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GnRH antagonist
- Development stage
- Unknown
- Lead developer
- Minia University
- Modality
- Peptides
- Administration
- Subcutaneous
01
Overview
GnRH-Minia University-infertility refers to the gonadotropin-releasing hormone (GnRH) antagonist utilized in clinical research at Minia University for the treatment of infertility. Specifically, it is employed in a short antagonist protocol for women undergoing Intracytoplasmic Sperm Injection (ICSI) who are predicted to be poor responders to standard ovarian stimulation. The drug functions by competitively binding to GnRH receptors in the anterior pituitary, which rapidly suppresses the release of endogenous gonadotropins, specifically luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This suppression is critical in assisted reproductive technology to prevent premature ovulation (LH surge) during the follicular development phase. In the Minia University study, this GnRH antagonist is evaluated as part of a regimen that includes the aromatase inhibitor letrozole and human menopausal gonadotropin (HMG) to enhance follicular recruitment and improve clinical pregnancy outcomes in poor responders.
- Other names
- GnRH-Minia University-infertilityGonadotropin-releasing hormone antagonist
02
Targets
GnRHR (Gonadotropin-releasing hormone receptor)
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