Drug intelligence / Profile preview

Godex

Development stage
Phase 3
Lead developer
Celltrion
Modality
Small Molecules
Administration
Oral
01

Overview

Godex is a hepatoprotective combination drug primarily used for the treatment of various liver disorders, including non-alcoholic fatty liver disease (NAFLD), chronic hepatitis, and liver cirrhosis. It is a multi-ingredient formulation typically composed of carnitine orotate, hepatic extract (antitoxic liver extract), adenosine, and B-vitamins including pyridoxine (B6), riboflavin (B2), and cyanocobalamin (B12). The drug's mechanism of action is multifaceted: carnitine facilitates the transport of long-chain fatty acids into the mitochondria for beta-oxidation, thereby reducing lipid accumulation in hepatocytes; orotic acid serves as a precursor for pyrimidine nucleotide synthesis, supporting DNA and RNA production for liver regeneration; and the B-vitamins act as essential cofactors for various metabolic enzymes. Godex is developed and marketed by Celltrion Pharm and is widely prescribed in South Korea for improving liver function and reducing elevated transaminase levels.

Brand names
GodexGodex Capsule
Other names
Carnitine orotate complexOrotic Acid Carnitine Complex
02

Targets

CRAT (Carnitine O-acetyltransferase)

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