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GoH3
- Development stage
- Unknown
- Lead developer
- Netherlands Cancer Institute
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Parenteral
01
Overview
GoH3 (also known as NKI-GoH3) is a rat monoclonal antibody (isotype IgG2a) that specifically targets the extracellular domain of the integrin alpha-6 subunit (CD49f, ITGA6). Originally developed at the Netherlands Cancer Institute, GoH3 is widely utilized as a research reagent to block the interaction between integrin alpha-6 (which forms heterodimers such as alpha-6/beta-1 and alpha-6/beta-4) and its ligand, laminin. It has been extensively studied in preclinical research models to investigate cell adhesion, migration, branching morphogenesis, gamete fusion, and tumor metastasis.
- Other names
- Anti-CD49f antibody clone GoH3Anti-CD-49f antibody clone GoH3Anti-CD 49f antibody clone GoH3Anti-Integrin alpha-6 antibody clone GoH3Rat anti-human CD49f antibody clone GoH3
02
Targets
ITGA6 (Integrin alpha-6)
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