Drug intelligence / Profile preview

gold-198

Development stage
Unknown
Modality
Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intracavitary, Interstitial, Intravenous, Intraarticular, Intratumoral
01

Overview

Gold-198 is a radioactive isotope of the element gold used primarily as a radiopharmaceutical for cancer therapy and diagnostic imaging. It emits beta radiation with a half-life of approximately 2.7 days. In medicine, it is most commonly administered as colloidal suspensions or in seed form for brachytherapy—an internal radiotherapy technique where the radioactive source is placed directly into or near tumor tissue to deliver localized irradiation while minimizing exposure to surrounding healthy tissues. Gold Au‑198 has been used in the treatment of various cancers including prostate cancer (as permanent seed implants), bladder tumors (via intracavitary instillation), and other malignancies; it has also served as a diagnostic aid in liver imaging and to estimate hepatic blood flow. Its mechanism of action relies on delivering cytotoxic ionizing radiation locally to induce cell death within malignant tissues[1][4][5][7].

Brand names
Aureotope
Other names
gold (198Au)gold (198 Au)gold, radioactive, colloidalgold (198Au) colloidalgold, Au-198Gold Au 198 colloidal
02

Targets

DNA

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