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gongliuning
- Development stage
- Unknown
- Lead developer
- Gansu Wuwei Pharmaceutical
- Modality
- Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Gongliuning is a Traditional Chinese Medicine (TCM) formulation primarily used for the treatment of uterine leiomyoma (uterine fibroids). Developed and manufactured by Gansu Taikang Pharmaceutical, it is a proprietary Chinese patent medicine approved by the NMPA. The formulation consists of multiple herbal ingredients, including *Sargassum*, *Sparganii Rhizoma*, and *Curcumae Rhizoma*, which are traditionally used to activate blood, resolve stasis, and dissipate nodules. Pharmacologically, Gongliuning is thought to exert its therapeutic effects by downregulating estrogen and progesterone receptors in fibroid tissue and promoting apoptosis of leiomyoma cells. It is frequently used in clinical practice in China either as a standalone therapy or in combination with western medications like mifepristone to reduce fibroid size and control symptoms such as heavy menstrual bleeding.
- Brand names
- GongliuningGongliuning Pian宫瘤宁片
- Other names
- Gongliuning tablets宫瘤宁
02
Targets
ER (Estrogen receptor)PR (Progesterone receptor)
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