Drug intelligence / Profile preview

gontivimab

Development stage
Discontinued
Lead developer
Sanofi
Modality
Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Inhalation
01

Overview

Gontivimab is a trivalent Nanobody (monoclonal antibody-derived therapeutic protein) that targets the prefusion F protein of respiratory syncytial virus (RSV). It binds with high affinity to antigenic site II of the RSV F protein and acts as a virus internalisation inhibitor and virus replication inhibitor. Gontivimab was developed for inhaled administration to treat RSV infections, particularly in infants and immunocompromised adults. The drug demonstrated potent antiviral activity *in vitro* and reduced RSV load in animal models. Clinical development reached phase 2 trials but was discontinued before approval[1][3][5][7].

Other names
anti-RSV protein F nanobody alx-0171anti-RSV nanobody
02

Targets

RSV F site II (RSV F antigenic site II)

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