gonyautoxin 3

**Gonyautoxin 3** is a naturally occurring marine toxin belonging to the group of paralytic shellfish poisons known as gonyautoxins, which are sulfated derivatives of saxitoxin. It functions as a highly selective **blocker of voltage-gated sodium channels** (VGSCs), inhibiting sodium ion influx in excitable cells and thereby preventing action potential propagation. This property leads to neuromuscular blockade and paralysis at sufficient concentrations. Gonyautoxin 3 is under investigation as an analgesic for acute pain, such as low back pain and for perioperative pain control after procedures like total knee arthroplasty. It is structurally classified as a small molecule, bis-guanidinium derivative, and is typically detected in the context of marine toxin monitoring. The compound is being developed as part of mixtures (notably with gonyautoxin 2) for clinical use.

Brand names

NAVX-010NAVX010NAVX 010

Other names

(+)-gonyautoxin 311β-hydroxysaxitoxin 11-sulfate1h,10h-pyrrolo(1,2-c)purine-9,10,10-triol 2,6-diamino-4-((aminocarbonyl)oxy)methyl-3a,4,8,9-tetrahydro-9-(hydrogen sulfate) 11-sulfate