gossypin

Gossypin is a naturally occurring flavonoid glycoside primarily isolated from the plant Hibiscus vitifolius and other species in the Malvaceae family. It is classified as a pentahydroxy glucosyl flavone. Gossypin exhibits diverse pharmacological activities including antioxidant, anti-inflammatory, neuroprotective, anticancer/antitumor (notably against melanoma and glioma), antidiabetic effects, cardioprotective properties (notably in ischemia/reperfusion injury models), and potential wound healing modulation. Mechanistically, it acts through multiple pathways such as inhibition of NF-kappaB activation via transforming growth factor beta–activated kinase 1 (TAK1), direct inhibition of kinases like BRAFV600E and CDK4 (implicated in cancer cell proliferation), regulation of Chk1/Cdc25C signaling in glioma cells, modulation of JAK/STAT signaling pathways and PI3K/Akt/mTOR pathway activity. Gossypin’s broad bioactivity profile has made it a subject of interest for further preclinical development as an adjunct or alternative therapy for cancer (especially melanoma) and inflammatory diseases[1][2][6][9].

Other names

gossypetin 8-glucosidegossypetin8-glucosidegossypetin-8-glucosidegossypetin 8-O-glucosidegossypetin8-O-glucosidegossypetin-8-O-glucoside3,5,7,8,3',4'-hexahydroxyflavone-8-glucoside2-(3,4-dihydroxyphenyl)-8-(beta-D-glucopyranosyloxy)-3,5,7-trihydroxy-4H-1-benzopyran-4-one