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GOVX-B21
- Development stage
- Discontinued
- Lead developer
- GeoVax Labs
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Live Vector Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
**GOVX-B21** is a preventive and therapeutic HIV vaccine candidate developed by GeoVax Labs using a DNA/MVA prime-boost platform. It expresses HIV clade B Gag, Pol, and Env proteins to form virus-like particles (VLPs) that mimic the virus structure, inducing robust T-cell and antibody responses. Distinct from GOVX-B11, GOVX-B21 co-expresses the genetic adjuvant **granulocyte-macrophage colony-stimulating factor (GM-CSF)** in the DNA prime to enhance immunogenicity, particularly for therapeutic use in HIV-infected patients on antiretroviral therapy. Evaluated in Phase 1 trials like HVTN 094 for prevention and planned follow-on studies for therapy, it showed good safety but no significant preventive benefit over the unadjuvanted version, leading to a shift toward advancing GOVX-B11.
- Other names
- GOVX B21
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