gp100 antigen

gp100 antigen is a melanoma-associated glycoprotein highly expressed in melanocytes and melanoma cells. It serves as a tumor-associated antigen and has been investigated as an immunotherapeutic target, particularly in vaccine formulations designed to stimulate cytotoxic T cell responses against tumors expressing this protein. The immune response is typically HLA-A2-restricted, leading to targeted lysis of melanoma cells. Clinical trials have explored its use in metastatic melanoma, including as part of cancer vaccines and gene therapies[1][2][3][4].

Other names

MELANOCYTE PROTEIN PMELMelanocyte protein Pmel 17MELANOCYTES LINEAGE-SPECIFIC ANTIGEN GP100MELANOMA-ASSOCIATED ME20 ANTIGENPREMELANOSOME PROTEIN