gp130 inhibitor

A gp130 inhibitor is a therapeutic agent that targets glycoprotein 130 (gp130), also known as IL6ST, a common signal-transducing receptor subunit for the IL-6 family of cytokines. By blocking gp130, these inhibitors disrupt the IL-6/GP130/STAT3 signaling axis, which plays a critical role in promoting tumor cell survival, chemoresistance, and inflammation. This class includes small molecules like SC144 and the repurposed drug bazedoxifene, as well as emerging biologic approaches such as nanobodies. Preclinical research has demonstrated their potential in treating various cancers, including glioblastoma, pancreatic ductal adenocarcinoma (PDAC), and hepatocellular carcinoma, often by sensitizing tumors to existing therapies like temozolomide or sorafenib.

Other names

gp130 inhibitorgp-130 inhibitorgp 130 inhibitorIL6ST inhibitorIL-6ST inhibitorIL 6ST inhibitorGlycoprotein 130 inhibitorGlycoprotein130 inhibitorGlycoprotein-130 inhibitor