Drug intelligence / Profile preview

GP2013 + chemotherapy

Development stage
Unknown
Lead developer
Sandoz
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous, Oral
01

Overview

GP2013 + chemotherapy is a combination therapy consisting of GP2013, a biosimilar to rituximab, together with a standard chemotherapy regimen. GP2013 is a monoclonal antibody that targets the CD20 protein on B lymphocytes, contributing to the destruction of malignant lymphoma cells. The chemotherapy typically given in this combination is CVP (cyclophosphamide, vincristine, and prednisolone/prednisone), which has cytotoxic effects on dividing cancer cells. This regimen has been investigated as a first-line treatment for follicular lymphoma, aiming to compare its efficacy and safety to rituximab plus chemotherapy[1][2][3][4][5].

02

Targets

TUBB (Tubulin (alpha and beta subunits))GR (Glucocorticoid receptor)CD20 (B-lymphocyte antigen CD20)DNA

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