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GPBBzT2
- Development stage
- Preclinical
- Lead developer
- Wellington Zhaotai Therapies
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
GPBBzT2 is a chimeric antigen receptor (CAR) T-cell therapy developed by Wellington Zhaotai for the treatment of liver cancer, specifically hepatocellular carcinoma. The therapy is engineered to target Glypican-3 (GPC3), a cell-surface oncofetal antigen that is highly expressed in liver cancer cells but has limited expression in healthy adult tissues. The CAR construct features a second-generation design incorporating a 4-1BB (CD137) co-stimulatory domain and a CD3-zeta signaling domain, which are intended to enhance the activation, metabolic fitness, and long-term persistence of the T cells within the tumor microenvironment. The "T2" suffix refers to the company's proprietary T2 CAR-T platform. Currently, GPBBzT2 is in the preclinical stage of development.
- Other names
- Wellington Zhaotai GPC3 CAR-TGPC3-4-1BB-CD3z CAR-TGPC-3-4-1BB-CD3z CAR-TGPC 3-4-1BB-CD3z CAR-T
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