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GPC-1-targeted CAR-T
- Development stage
- Preclinical
- Lead developer
- Carina Biotech
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
GPC-1-targeted CAR-T is an experimental chimeric antigen receptor T-cell (CAR-T) therapy being co-developed by Carina Biotech and GlyTherix for the treatment of solid tumors. The therapy utilizes T cells engineered to express a CAR specific for Glypican-1 (GPC-1), a cell-surface heparan sulfate proteoglycan that is highly expressed in several cancers, including prostate, colorectal, and ovarian malignancies, while showing limited expression in normal tissues. By targeting GPC-1, the CAR-T cells are designed to selectively bind to and destroy tumor cells through T-cell-mediated killing. The program is currently in the preclinical stage of development, aiming to provide a potent and specific treatment option for patients with GPC-1-positive solid tumors.
- Other names
- GPC-1 CAR-TGPC1 CAR-TGPC 1 CAR-TGPC-1-targeted CAR-T (Glypican-1)
02
Targets
GPC1 (Glypican-1)
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