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GPC3-IRDye800

Development stage: Unknown
Lead developer: Chinese Academy of Sciences
Modality: Antibody-Based Therapeutics
Administration: Intravenous

Overview

GPC3-IRDye800 (also known as GPC3-IRDye800CW or Anti-GPC3-IRDye800CW) is a glypican-3 (GPC3)-targeted near-infrared (NIR) fluorescent imaging agent developed for fluorescence-guided surgery (FGS) and intraoperative tumor boundary identification in patients with hepatocellular carcinoma (HCC). It consists of a GPC3-targeting monoclonal antibody conjugated to the near-infrared fluorescent dye IRDye800CW. Upon administration, the agent selectively binds to GPC3, which is highly overexpressed on the surface of HCC cells but absent in normal liver tissue, allowing real-time visualization of tumor margins and aiding complete surgical resection.

Other names: Anti-GPC3-IRDye800CWAnti-GPC-3-IRDye800CWAnti-GPC 3-IRDye800CWGPC3-IRDye800CWGPC-3-IRDye800CWGPC 3-IRDye800CWanti-glypican-3-IRDye800CWanti-glypican3-IRDye800CWanti-glypican 3-IRDye800CW

Targets

GPC3 (Glypican-3)

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