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GPRC5D-NKG2D BsAb
- Development stage
- Preclinical
- Lead developer
- City of Hope National Medical Center
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
GPRC5D-NKG2D BsAb is a bispecific antibody (BsAb) designed for the treatment of multiple myeloma. It is constructed on a human IgG4 platform and features single-chain variable fragments (scFv) that target the orphan G protein-coupled receptor class C group 5 member D (GPRC5D) on myeloma cells and the activating receptor NKG2D on natural killer (NK) cells. Developed by researchers at the City of Hope National Medical Center, the antibody acts as an NK-cell engager, bridging NK cells to tumor cells to facilitate targeted cytotoxicity. In preclinical studies, it has been evaluated both as a purified therapeutic protein and as a secreted component of engineered BCMA-CAR NK cells to address tumor heterogeneity and antigen escape in multiple myeloma models.
- Other names
- GPRC5D-NKG2D bispecific antibodyGPRC-5D-NKG2D bispecific antibodyGPRC 5D-NKG2D bispecific antibody
02
Targets
NKG2D (Natural killer group 2 member D receptor)GPRC5D
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