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GQ-501
- Development stage
- Preclinical
- Lead developer
- Pacira BioSciences
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies
- Administration
- Intraarticular
01
Overview
GQ-501 is a gene therapy drug candidate developed for the treatment of osteoarthritis. It is a helper-dependent adenoviral vector that expresses two therapeutic proteins: proteoglycan 4 (also known as lubricin) and interleukin-1 receptor antagonist (IL-1Ra). The mechanism of action involves stimulating IL-1Ra, which inhibits inflammatory signaling mediated by interleukin 1, and modulating PRG4/lubricin, which plays a role in joint lubrication and cartilage protection. The drug is being developed by GQ Bio Therapeutics GmbH (formerly GeneQuine Biotherapeutics GmbH), with its highest development phase reported as preclinical[1][2].
- Other names
- HCAd-NFkB-IL-1RA-PRG4HCAd-NFkB-IL1RA-PRG4HCAd-NFkB-IL 1RA-PRG4HCAd-NFkB::IL-1RA/PRG4HCAd-NFkb::IL-1Ra; EF1::Prg4HCAd-NFκB::IL-1Ra-EF1::Prg4
02
Targets
IL1R1 (Interleukin-1 Receptor Type 1)IL1RN (Interleukin-1 receptor antagonist)PRG4 (Proteoglycan 4)
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