gramicidin + neomycin sulfate + polymyxin b

Gramicidin + neomycin sulfate + polymyxin b is a fixed-dose **triple-antibiotic ophthalmic solution** used for the topical treatment of superficial bacterial infections of the external eye and its adnexa, including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, and blepharoconjunctivitis. The combination provides broad-spectrum antibacterial coverage through complementary mechanisms: **neomycin** is an aminoglycoside that inhibits bacterial protein synthesis by binding the 30S ribosomal subunit, **polymyxin b** is a polypeptide antibiotic that disrupts the outer and cytoplasmic membranes of susceptible Gram-negative bacteria through interaction with membrane phospholipids, and **gramicidin** is a peptide antibiotic that forms transmembrane ion channels and increases membrane permeability, particularly against Gram-positive organisms. The product has been marketed as an ophthalmic prescription drug, including under the brand **Neosporin**, and has been associated with Bausch & Lomb.

Brand names

Neosporin

Other names

neomycin and polymyxin b sulfates and gramicidin ophthalmic solutionneomycin sulfate + polymyxin b sulfate + gramicidingramicidin + neomycin sulfate + polymyxin b ophthalmic solution