Drug intelligence / Profile preview

graminaceae allergenic extract

Development stage
Unknown
Lead developer
Lofarma
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Percutaneous, Sublingual, Subcutaneous
01

Overview

Graminaceae allergenic extract is a standardized biologic allergen extract derived from grass pollen, developed by Lofarma S.p.A. for the diagnosis and treatment of respiratory allergies, including allergic rhinitis and allergic asthma. It acts as an immunomodulator by targeting the IgE-mediated allergic response pathway, aiming to induce desensitization and clinical tolerance in patients sensitized to grass pollens. The extract is utilized in both diagnostic skin prick testing and allergen immunotherapy (AIT). Clinical development has included Phase 2 biological standardization studies to define its potency in histamine equivalent prick (HEP) units and establish reference preparations.

Other names
grass pollen allergenic extractGraminaceae extract
02

Targets

TCR (T cell antigen receptor complex)BCR (Allergen-specific B-cell receptor)IgE (Immunoglobulin E)

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