granisetron

Granisetron is a **small-molecule selective serotonin 5-hydroxytryptamine 3 receptor antagonist** used as an antiemetic for the prevention and treatment of chemotherapy-induced nausea and vomiting and, in some products, postoperative nausea and vomiting. By blocking peripheral and central 5-HT3 receptors involved in the emetic reflex, granisetron reduces nausea and vomiting triggered by cytotoxic therapy. The drug has been developed and commercialized in multiple formulations, including intravenous and oral immediate-release products, a transdermal patch marketed as Sancuso, and an extended-release subcutaneous injection marketed as Sustol. The provided sources specifically confirm granisetron use in oncology supportive care, including FDA-approved products for prevention of chemotherapy-induced nausea and vomiting and multiple clinical studies in breast cancer and other chemotherapy settings.

Brand names

SancusoSustolKytril

Other names

格拉司琼