Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Granulin
- Development stage
- Preclinical
- Modality
- Recombinant Proteins and Enzymes, Peptides
- Administration
- Intrathalamic, Intra-cisterna Magna, Intravenous
01
Overview
Granulin, also known as progranulin (PGRN), is a multifunctional protein involved in various biological processes including lysosomal function, neuroinflammation, and neuronal survival. It is the precursor to several granulin motifs. Mutations in the GRN gene, which encodes progranulin, are a significant cause of hereditary Frontotemporal Dementia (FTD) due to reduced progranulin levels. Therapeutically, granulin or its derived peptides are being investigated for their potential to restore progranulin levels in FTD or for applications like wound healing. Conversely, elevated progranulin levels are associated with increased malignancy in tumors and are being studied as a biomarker for conditions such as prediabetes and diabetes.
- Other names
- ProgranulinPGRNGRN
02
Targets
CTSD (Cathepsin D)GBA1 (Glucosylceramidase)HEXA (Hexosaminidase subunit alpha)GRN (Progranulin)
Beyond the preview
Go deeper on Granulin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Granulin.