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Granulin
- Development stage
- Preclinical
- Modality
- Recombinant Proteins and Enzymes, Peptides
- Administration
- Intrathalamic, Intra-cisterna Magna, Intravenous
01
Overview
Granulin, also known as progranulin (PGRN), is a multifunctional protein involved in various biological processes including lysosomal function, neuroinflammation, and neuronal survival. It is the precursor to several granulin motifs. Mutations in the GRN gene, which encodes progranulin, are a significant cause of hereditary Frontotemporal Dementia (FTD) due to reduced progranulin levels. Therapeutically, granulin or its derived peptides are being investigated for their potential to restore progranulin levels in FTD or for applications like wound healing. Conversely, elevated progranulin levels are associated with increased malignancy in tumors and are being studied as a biomarker for conditions such as prediabetes and diabetes.
- Other names
- ProgranulinPGRNGRN
02
Targets
HEXA (Hexosaminidase subunit alpha)CTSD (Cathepsin D)GBA1 (Glucosylceramidase)
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