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granulocyte-macrophage colony-stimulating factor + interleukin-2
- Development stage
- Unknown
- Lead developer
- Bayer
- Modality
- Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
A combination immunotherapy approach using two cytokines with complementary functions. Granulocyte-macrophage colony-stimulating factor (GM-CSF) leads to dendritic cell/macrophage priming and activation, and increases IL-2 receptor expression on T lymphocytes. Interleukin-2 (IL-2) creates lymphokine-activated killer cells and tumor-infiltrating lymphocyte cells. The combination has shown synergistic antitumor effects in various cancer types.
- Brand names
- ProleukinLeukine
- Other names
- GM-CSF + IL-2sargramostim + aldesleukin
02
Targets
CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)IL-2R (Interleukin-2/interleukin-15 receptor complex)
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