granulocyte-macrophage colony-stimulating factor DNA

Granulocyte-macrophage colony-stimulating factor DNA refers to **DNA plasmids or constructs encoding the protein GM-CSF**, intended to induce in vivo expression of GM-CSF following delivery (often as gene therapy, genetic vaccine, or as an adjuvant to vaccination). GM-CSF is a cytokine that stimulates the production, differentiation, and activation of granulocytes and macrophages from hematopoietic precursors, enhancing both innate and adaptive immunity. GM-CSF DNA has been used as a direct immunostimulatory agent, as a genetic adjuvant in DNA vaccines (for example, co-delivery of GM-CSF DNA with tumor antigen DNA for cancer immunotherapy), or to augment dendritic cell responses for enhanced antigen presentation. Mechanistically, expressed GM-CSF binds to granulocyte-macrophage colony-stimulating factor receptor on target hematopoietic cells, promoting proliferation, activation, and enhanced immune response, including stimulation of neutrophil, monocyte, macrophage, and dendritic cell populations[1][2][4]. Clinical data exists for use of GM-CSF DNA as a genetic adjuvant (often via epidermal or intramuscular gene delivery, e.g. “gene gun” or electroporation) in cancer vaccine immunotherapy[4].

Other names

GM-CSF DNAGM-CSF geneGM-CSF cDNACSF2 DNACSF-2 DNACSF 2 DNAgranulocyte-macrophage colony stimulating factor DNAGM-CSF plasmid DNA