grape polyphenol concentrate

Grape polyphenol concentrate is a dietary supplement derived from grapes, rich in bioactive polyphenolic compounds. It is being investigated for its potential to manage chronic systemic inflammation in patients with Type 1 Diabetes Mellitus (T1DM). The concentrate acts primarily by inhibiting the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway, which is a central regulator of the inflammatory response to metabolic endotoxemia (e.g., lipopolysaccharides entering circulation from the gut). By suppressing this pathway and providing antioxidant effects, it reduces markers of systemic inflammation such as C-reactive protein (CRP). It is considered a non-pharmacological intervention to reduce cardiovascular risk and manage inflammatory complications in diabetic patients.

Other names

grape polyphenols