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Grapefruit pectin is a complex polysaccharide fiber extracted from the peel and pulp of grapefruit. It is a form of soluble dietary fiber known for its gelling properties and is sometimes used as a supplement. Mechanistically, grapefruit pectin increases intestinal bulk, binds bile acids, and reduces cholesterol absorption in the gut, which can lower serum LDL (bad) cholesterol. Animal and human studies suggest it may modestly decrease total and LDL cholesterol, and benefit digestive health by acting as a prebiotic, improving stool consistency, and potentially reducing inflammation in the colon[1][2][5][6][9]. There is limited evidence for effects in weight management and colon cancer prevention. Grapefruit pectin, like other citrus pectins, may interfere with absorption of certain medications. It is generally considered safe when consumed in amounts found in food. Commercial grapefruit pectin supplements are produced by several dietary supplement manufacturers.
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