Drug intelligence / Profile preview

Grass allergen extract

Development stage
Approved
Lead developer
ALK Abelló
Modality
Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
Administration
Sublingual
01

Overview

Grass allergen extracts are standardized biologic preparations derived from the pollens of grasses such as timothy (*Phleum pratense*) and other related species. They are used as immunotherapy to treat allergic rhinitis with or without conjunctivitis caused by sensitivity to grass pollens. These extracts work by gradually desensitizing the immune system to specific allergens through repeated sublingual administration, thereby reducing symptoms like sneezing, runny nose, itchy eyes, and congestion during pollen season. The mechanism of action is based on modulating the immune response to reduce hypersensitivity reactions upon exposure to natural allergens[1][2][3][4][5][8]. Grass allergen extracts do not provide immediate symptom relief but can induce long-term tolerance when taken regularly before and during allergy seasons[4]. Major products include Grastek (timothy grass), Oralair (mixed grasses), and Grazax (timothy grass)[1][2][3][8].

Brand names
GrastekOralairGrazax
Other names
timothy grass pollen allergen extractmixed grass pollens allergen extractstandardized grass pollen [timothy (Phleum pratense)] allergen extract
02

Targets

Timothy grass-specific IgE (Timothy grass-specific immunoglobulin E)PRR (Pattern recognition receptors)

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