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GrB-Fc-SD1
- Development stage
- Preclinical
- Lead developer
- AbBC Therapies
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
GrB-Fc-SD1 is a preclinical-stage recombinant fusion protein therapeutic being developed by AbBC Therapies for the treatment of pancreatic and ovarian cancers. The drug is composed of a human single-domain antibody (SD1) that specifically targets Region III of the mesothelin glycoprotein, fused to a Granzyme B-Fc construct. This fusion protein is designed to deliver the cytotoxic serine protease Granzyme B directly into mesothelin-overexpressing tumor cells. Upon internalization, Granzyme B triggers apoptosis via both caspase-dependent and caspase-independent pathways. Preclinical studies have demonstrated nanomolar-range cytotoxicity and significant in vivo efficacy in tumor xenograft models.
- Other names
- Granzyme B-Fc-SD1SD1-GrB-FcSD-1-GrB-FcSD 1-GrB-Fc
02
Targets
Mesothelin
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