Drug intelligence / Profile preview

green rooibos extract

Development stage
Unknown
Lead developer
South African Medical Research Council
Modality
Small Molecules
Administration
Oral
01

Overview

Green rooibos extract is a specialized, unfermented preparation of the South African plant *Aspalathus linearis*, processed to preserve high concentrations of the C-glucosyl dihydrochalcone aspalathin. Unlike traditional fermented red rooibos, the green extract maintains a distinct polyphenolic profile with potent antioxidant and metabolic-modulating properties. Its primary mechanism of action involves the activation of AMP-activated protein kinase (AMPK) and the upregulation of glucose transporter type 4 (GLUT4), which enhances glucose uptake and improves insulin sensitivity. Additionally, it has been shown to regulate lipid metabolism by suppressing lipogenic gene expression and reducing hepatic lipid accumulation. Developed primarily as a nutraceutical or dietary supplement, it is being investigated for its potential to treat type 2 diabetes, dyslipidemia, and metabolic syndrome, both as a monotherapy and as an adjunct to conventional pharmaceuticals like metformin or statins.

Other names
Aspalathin-rich green rooibos teaAspalathus linearis extractaspalathin-rich green rooibos extractunfermented rooibos extract
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)PPARG (Peroxisome proliferator-activated receptor gamma)

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