Green tea + α-glucosyl hesperidin

The combination of green tea and α-glucosyl hesperidin (GT-gH) is a dietary supplement that has been studied for its potential health benefits, particularly in preventing obesity. This combination leverages the beneficial properties of both components: green tea catechins (especially epigallocatechin-3-O-gallate or EGCG) and α-glucosyl hesperidin, a modified form of the citrus bioflavonoid hesperidin. ## Composition and Properties GT-gH typically contains around 146 mg of EGCG from green tea and 178 mg of α-glucosyl hesperidin[1]. The α-glucosyl hesperidin component is a modified form of hesperidin created through enzymatic transglucosylation, which significantly improves its water solubility (approximately 10,000 times more soluble than native hesperidin)[2][4]. This enhanced solubility improves bioavailability, making the combination potentially more effective than either component alone. ## Mechanisms of Action The combination works through multiple mechanisms: - **Anti-obesity effects**: GT-gH has been shown to prevent weight gain and reduce body mass index (BMI) in clinical trials[1]. - **Metabolic benefits**: The combination can decrease triglyceride levels, body fat percentage, visceral fat levels, and improve blood LDL/HDL ratio, particularly in individuals under 50 years of age[1]. - **Antioxidant activity**: Both components have strong antioxidant properties that may contribute to their health benefits[2][5]. - **Anti-inflammatory effects**: The combination exhibits anti-inflammatory properties that may contribute to its overall health benefits[2]. ## Clinical Evidence A randomized, placebo-controlled, double-blinded clinical trial with 60 healthy Japanese adults aged 30-75 years demonstrated that daily consumption of GT-gH for 12 weeks was safe and effective in preventing weight gain and reducing BMI compared to placebo[1]. The anti-obesity effects were more pronounced in participants under 50 years of age, who showed decreases in triglycerides and body fat percentage at week 6, and reductions in visceral fat level, body fat percentage, body weight, BMI, and blood LDL/HDL ratio at week 12[1]. ## Safety Profile Physical, hematological, blood biochemical, and urine examinations from clinical trials have shown that GT-gH is generally safe for consumption[1]. However, as with any supplement containing hesperidin derivatives, caution should be exercised in certain populations: - People with bleeding disorders or those taking anticoagulants - Individuals who have recently undergone surgery - Those taking certain medications, particularly calcium channel blockers like celiprolol, diltiazem, and verapamil, as hesperidin may affect their absorption and efficacy[3][4] - Pregnant or breastfeeding women - People with allergies or intolerance to flavonoids[4] The combination of green tea and α-glucosyl hesperidin represents an innovative approach to leveraging natural compounds for potential health benefits, particularly in weight management and metabolic health.

Other names

GT-gH