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green tea extract
- Development stage
- Phase 3
- Lead developer
- Taipei City Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Green tea extract (GTE) is a botanical extract derived from the leaves of *Camellia sinensis*, primarily characterized by its high concentration of polyphenolic catechins, most notably (-)-epigallocatechin-3-gallate (EGCG). GTE is widely utilized as a dietary supplement and investigated as a therapeutic agent for obesity, metabolic syndrome, and cardiovascular health. Its mechanism of action involves the inhibition of catechol-O-methyltransferase (COMT), which leads to increased levels of norepinephrine and subsequent stimulation of thermogenesis and fat oxidation. Additionally, GTE has been shown to activate the AMP-activated protein kinase (AMPK) pathway, reduce intestinal lipid absorption, and modulate obesity-related hormones such as adiponectin, ghrelin, and leptin. Clinical studies have demonstrated its potential to reduce body weight, body mass index (BMI), waist circumference, and low-density lipoprotein cholesterol (LDL-C), particularly when combined with endurance training or dietary modifications.
- Brand names
- ExoliseVitaSage Green Tea Extract
- Other names
- Camellia sinensis leaf extractGTEgreen tea catechinsgreen tea polyphenols
02
Targets
Cyp (Cyclophilin family)DNMT (DNA methyltransferase)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)AMPK (Adenosine monophosphate–activated protein kinase)AdipoR (Adiponectin receptor)COMT (Catechol-O-methyltransferase)GHRL (Ghrelin)
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