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green tea leaf extract decaffeinated
- Development stage
- Unknown
- Lead developer
- Ain Shams University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Decaffeinated green tea leaf extract is a botanical substance derived from *Camellia sinensis*, characterized by a high concentration of polyphenolic catechins, most notably epigallocatechin gallate (EGCG). In a clinical program led by Ain Shams University, this extract is being investigated as a therapeutic intervention for prediabetes in obese pediatric patients. The extract is administered as a 300 mg film-coated tablet in combination with metformin. Its mechanism of action involves the reduction of oxidative stress and systemic inflammation through the inhibition of the NF-κB pathway and the modulation of adipokines such as leptin and adiponectin. The primary clinical goal is to improve insulin sensitivity (measured via HOMA-IR) and prevent the progression of prediabetes to type 2 diabetes mellitus in children and adolescents.
- Brand names
- Mepaco Green Tea
- Other names
- Camellia sinensis leaf extractGreen tea extractGTEEpigallocatechin gallate
02
Targets
RELA (Nuclear Factor Kappa B Subunit p65)
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