Drug intelligence / Profile preview

Green tea mouthwash

Development stage
Unknown
Lead developer
Cairo University
Modality
Small Molecules
Administration
Topical
01

Overview

Green tea mouthwash is an herbal oral rinse formulated from the extract of *Camellia sinensis* leaves, containing bioactive polyphenols such as epigallocatechin-3-gallate (EGCG). In research conducted by Cairo University, it is evaluated for its efficacy in treating plaque-induced gingivitis, particularly in pediatric populations. The mouthwash functions through a multi-targeted mechanism: it exerts antimicrobial effects by inhibiting the growth and adhesion of dental plaque bacteria (e.g., *Streptococcus mutans*), and it provides anti-inflammatory benefits by reducing the expression of pro-inflammatory cytokines and inhibiting matrix metalloproteinases (MMPs) that contribute to tissue degradation. It is positioned as a natural, non-staining alternative to traditional chemical agents like chlorhexidine.

Other names
Camellia sinensis mouthwashGreen tea extract mouthwash
02

Targets

IL8 (C-X-C Motif Chemokine Ligand 8)IL1B (Interleukin-1 beta)MMP8 (Neutrophil collagenase)MMP9 (Matrix metalloproteinase-9)TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)MMP3 (Matrix metalloproteinase-3)

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