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GreenLantern mRNA LNP
- Development stage
- Unknown
- Lead developer
- Moderna
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Parenteral
01
Overview
GreenLantern mRNA LNP is a research-grade reporter mRNA formulation encapsulated in lipid nanoparticles (LNPs). It encodes the GreenLantern protein, a high-intensity green fluorescent protein variant optimized for brightness and stability. In preclinical research, particularly in studies involving mRNA-LNP delivery platforms, this agent is utilized as a non-therapeutic control to assess transfection efficiency and protein expression levels across various cell types, including leukemia cell lines and primary patient blasts. It serves as a benchmark for evaluating the delivery performance of functional mRNA candidates, such as those encoding the CEBPA transcription factor for the treatment of acute myeloid leukemia (AML).
- Other names
- GreenLantern mRNA-LNP
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