Drug intelligence / Profile preview

Greenselect Phytosome + piperine

Development stage
Unknown
Lead developer
Indena
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Greenselect Phytosome + piperine is a combination dietary supplement consisting of Greenselect Phytosome—a proprietary, caffeine-free green tea (Camellia sinensis) catechin extract formulated with lecithin to enhance bioavailability—and piperine, an alkaloid derived from black pepper (Piper nigrum). The primary active component in Greenselect Phytosome is epigallocatechin-3-O-gallate (EGCG), standardized to at least 13%, with total polyphenols between 19–25% and caffeine content ≤0.1%. Piperine acts as a bioenhancer by inhibiting drug-metabolizing enzymes and efflux transporters such as CYP3A4 and P-glycoprotein, thereby increasing the absorption and systemic availability of co-administered compounds. This combination has been clinically studied for weight management—particularly for supporting weight maintenance after intentional weight loss—and improving metabolic parameters such as blood lipid profile and blood pressure. The formulation is developed using Indena’s Phytosome technology to optimize oral absorption of polyphenols[1][2][3][4][6].

Other names
GSP + piperinegreen tea phytosome + piperinedecaffeinated green tea extract phytosome + piperine
02

Targets

CYP3A4 (Cytochrome P450 3A4)COMT (Catechol-O-methyltransferase)ABCB1 (P-glycoprotein)

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