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Group T-Bursa Yuksek Ihtisas Training and Research Hospital-postoperative pain
- Development stage
- Unknown
- Lead developer
- Bursa Yuksek Ihtisas Training and Research Hospital
- Modality
- Small Molecules
- Administration
- Parenteral
01
Overview
"Group T-Bursa Yuksek Ihtisas Training and Research Hospital-postoperative pain" refers to a specific treatment arm in a clinical trial conducted at Bursa Yuksek Ihtisas Training and Research Hospital. This arm utilizes a combination of the local anesthetic bupivacaine and the opioid analgesic tramadol for the management of postoperative pain in patients undergoing laparoscopic cholecystectomy. The protocol involves an ultrasound-guided External Oblique and Rectus Abdominis plane (EXORA) block using 0.25% bupivacaine (administered with a specific 2-minute injection duration in Group T) to provide regional analgesia, supplemented by intravenous tramadol via patient-controlled analgesia (PCA). Bupivacaine acts by blocking voltage-gated sodium channels to inhibit nerve conduction, while tramadol provides systemic analgesia through mu-opioid receptor agonism and inhibition of serotonin and norepinephrine reuptake. The study specifically investigates how the duration of the fascial plane block injection influences the spread of the local anesthetic and the overall success of the block.
- Other names
- Group T-Bursa Yuksek Ihtisas Training and Research Hospital-postoperative pain
02
Targets
SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)MOR (Mu opioid receptor)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)
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