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GRT-R910
- Development stage
- Phase 1
- Lead developer
- Gritstone Oncology
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular
01
Overview
GRT-R910 is a next-generation self-amplifying mRNA (samRNA) vaccine candidate developed by Gritstone bio for the prevention of COVID-19. As part of the CORAL program, it is designed to provide broad and durable immunity against SARS-CoV-2 variants by targeting both the viral spike protein and highly conserved T cell epitopes. The self-amplifying nature of the mRNA allows for lower dosing compared to traditional mRNA vaccines while potentially inducing a more robust and prolonged immune response. The program has received significant support from BARDA (Project NextGen), CEPI, and the Bill & Melinda Gates Foundation, and utilizes lipid nanoparticle (LNP) delivery technology licensed from Genevant Sciences.
- Other names
- CORAL vaccine
02
Targets
SARS-CoV-2 spikeConserved non-spike SARS-CoV-2 protein regions
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