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GS24-B025
- Development stage
- Unknown
- Lead developer
- Changchun GeneScience Pharmaceutical
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**GS24-B025** is a highly differentiated bispecific antibody-drug conjugate (bsADC) targeting **CDH17** and **CEA**, developed for the treatment of advanced solid tumors, particularly **colorectal cancer** and other gastrointestinal (GI) malignancies. It leverages dual antigen specificity to enhance tumor cell targeting and internalization, delivering a cytotoxic payload selectively within the tumor microenvironment to minimize off-target toxicity. The drug has received clinical trial approval from China's NMPA and is advancing in early-phase studies evaluating safety, tolerability, pharmacokinetics, and preliminary efficacy in patients with advanced solid tumors.[1][3][5]
- Other names
- HS-20110HS20110HS 20110
02
Targets
CDH17 (Cadherin-17)
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