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GS24-B057
- Development stage
- Preclinical
- Lead developer
- Changchun GeneScience Pharmaceutical
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**GS24-B057** is a bispecific antibody-drug conjugate (ADC) designed to target both **Nectin-4** and **Trop-2**, two cell surface antigens overexpressed in multiple solid tumors. Developed to enhance clinical efficacy while minimizing toxicity, it features a dual-targeting mechanism with a specified drug-to-antibody ratio (DAR). Preclinical studies position it as a potential best-in-class candidate for treating various solid tumors by delivering cytotoxic payloads selectively to tumor cells expressing these targets.[1][3][5]
02
Targets
TACSTD2 (Tumor-associated calcium signal transducer 2)PVRL4 (Nectin cell adhesion molecule 4)
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