Drug intelligence / Profile preview

GSC-000829

Development stage
Preclinical
Lead developer
Changchun GeneScience Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

**GSC-000829** is a preclinical, selective fibroblast growth factor receptor 2 and 3 inhibitor being developed by **Changchun Genescience Pharmaceuticals** for FGFR-driven diseases. Publicly available sources describe it as a novel FGFR2/FGFR3-selective inhibitor with improved selectivity over FGFR1 and FGFR4, activity against tumors harboring FGFR2/3 fusions or mutations, and favorable preclinical pharmacokinetic and toxicity characteristics. An AACR 2025 abstract positions the program for **advanced solid tumors with FGFR2/3 aberrations**, while other public drug-database coverage also associates the asset with **achondroplasia**; no approved brand name, INN, dosage form, or route of administration has been publicly established from the sources reviewed.

02

Targets

FGFR4 (Fibroblast growth factor receptor 4)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR1 (Fibroblast growth factor receptor 1)

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