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GSI526
- Development stage
- Unknown
- Lead developer
- Ocean University of China
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
GSI526: sourced facts only. name: "Among the synthesized compounds, GSI526 emerged as a potent degrader, demonstrating efficient IRAK4 degradation in THP-1 cells with a DC₅₀ of 40.17 nM." [PMID:42097519]; target: "Among the synthesized compounds, GSI526 emerged as a potent degrader, demonstrating efficient IRAK4 degradation in THP-1 cells with a DC₅₀ of 40.17 nM." [PMID:42097519]; developer: "Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China." [PMID:42097519]; modality: "we designed and synthesized a novel proteolysis-targeting chimera (PROTAC) aimed at degrading IRAK4." [PMID:42097519]
02
Targets
IRAK4 (Interleukin-1 receptor associated kinase 4)
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