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GSK149203A
- Development stage
- Phase 1
- Lead developer
- GSK
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Protein Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
GSK149203A is a candidate vaccine developed by GSK (GlaxoSmithKline) for the prevention of cytomegalovirus (CMV) infection. It is a recombinant glycoprotein B (gB) subunit vaccine, designed to elicit an immune response against CMV by targeting the viral gB protein, which plays a key role in viral entry into host cells. The vaccine has been evaluated in clinical trials as a prophylactic measure to prevent CMV infections, particularly in populations at risk such as transplant recipients and seronegative individuals[1][2]. Its mechanism of action involves inducing antibodies that neutralize CMV by binding to the gB antigen.
- Other names
- GSK Biologicals' recombinant CMV gB vaccineCytomegalovirus glycoprotein vaccine
02
Targets
gB (Human cytomegalovirus glycoprotein B)
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