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GSK2036874A
- Development stage
- Phase 2
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
GSK2036874A is GSK's investigational **hexavalent pediatric combination vaccine** for active immunization against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and *Haemophilus influenzae* type b disease. It combines diphtheria-tetanus-whole-cell pertussis-hepatitis B, inactivated poliovirus, and Hib-conjugate vaccine components; three Phase 2 formulations differed only in their inactivated poliovirus antigen content. The candidate was evaluated as a single intramuscular booster dose in poliovirus-primed Filipino toddlers aged 12 to 24 months. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC3426081/))
- Other names
- DTPw-HBV-IPV/Hib vaccinediphtheria-tetanus-whole cell pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine
02
Targets
Diphtheria toxinPRNP (Cellular Prion Protein)HBsAg (Hepatitis B surface antigen)
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