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GSK2654909A is an unadjuvanted, monovalent inactivated split-virion influenza vaccine candidate developed by GSK. It is designed to provide active immunity against the H9N2 subtype of Influenza A, an avian influenza virus identified as having significant pandemic potential. The vaccine is manufactured in Quebec, Canada, using a process involving embryonated chicken eggs. In clinical studies, GSK2654909A has been evaluated for safety, reactogenicity, and immunogenicity in adults, often serving as a baseline comparator to adjuvanted formulations (such as GSK2654911A) to determine the necessity and impact of adjuvant systems in achieving protective antibody titers against avian-origin influenza antigens.
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