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GSK2838501A
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
GSK2838501A is an investigational protein subunit vaccine developed by GSK, designed to prevent acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The vaccine is a combination product targeting two common bacterial pathogens associated with COPD exacerbations: non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat). It typically incorporates three NTHi antigens (Protein D, Protein E, and PilA) and one Mcat antigen (UspA2), formulated with GSK's proprietary AS01E adjuvant system to enhance the immune response. The vaccine aims to reduce the frequency and severity of exacerbations by inducing protective antibody and T-cell responses against these pathogens.
- Other names
- NTHi-Mcat vaccineNTHi-Mcat-AS01ENTHi-Mcat-AS-01ENTHi-Mcat-AS 01ENTHi-Mcat candidate vaccine
02
Targets
M. catarrhalis (Moraxella catarrhalis)
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